Cooperative dynamics across distinct structural elements regulate PTP1B activity
نویسندگان
چکیده
منابع مشابه
Electronic and Structural Elements That Regulate the Excited-State Dynamics in Purine Nucleobase Derivatives
The excited-state dynamics of the purine free base and 9-methylpurine are investigated using experimental and theoretical methods. Femtosecond broadband transient absorption experiments reveal that excitation of these purine derivatives in aqueous solution at 266 nm results primarily in ultrafast conversion of the S2(ππ*) state to the vibrationally excited (1)nπ* state. Following vibrational an...
متن کاملNative thrombocidin-1 and unfolded thrombocidin-1 exert antimicrobial activity via distinct structural elements.
Chemokines (chemotactic cytokines) can have direct antimicrobial activity, which is apparently related to the presence of a distinct positively charged patch on the surface. However, chemokines can retain antimicrobial activity upon linearization despite the loss of their positive patch, thus questioning the importance of this patch for activity. Thrombocidin-1 (TC-1) is a microbicidal protein ...
متن کاملCTCF and cohesin regulate chromatin loop stability with distinct dynamics
Folding of mammalian genomes into spatial domains is critical for gene regulation. The insulator protein CTCF and cohesin control domain location by folding domains into loop structures, which are widely thought to be stable. Combining genomic and biochemical approaches we show that CTCF and cohesin co-occupy the same sites and physically interact as a biochemically stable complex. However, usi...
متن کاملCis-regulatory RNA elements that regulate specialized ribosome activity.
Recent evidence has shown that the ribosome itself can play a highly regulatory role in the specialized translation of specific subpools of mRNAs, in particular at the level of ribosomal proteins (RP). However, the mechanism(s) by which this selection takes place has remained poorly understood. In our recent study, we discovered a combination of unique RNA elements in the 5'UTRs of mRNAs that a...
متن کاملp-VERSION FINITE ELEMENTS IN STRUCTURAL DYNAMICS AND STABILITY
The performance of the finite element method (FEM) may be improved in three ways. The first is by the h-version to refine the finite element mesh and the second is by the p-version to increase the order of polynomial shape functions for a fixed mesh. The third is simultaneously to refine the mesh and increase the degrees of elements uniformly or selectively, called the h-p version, which is a c...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2020
ISSN: 0021-9258
DOI: 10.1074/jbc.ra120.014652